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摘要：
目的 探讨缺氧诱导因子-1 α单克隆抗体治疗SCID小鼠子宫内膜异位症的作用.方法 将30只皮下移植法造模成功的SCID小鼠随机分3组:对照组(n=10)、生理盐水组(n=10)和治疗组(n=10).对照组常规饲养,生理盐水组和治疗组分别在病灶内注射生理盐水和HIF-1α单克隆抗体(每只250μg/0.25ml),1周后重复注射1次,第2次治疗后1周处死3组SCID小鼠.测量比较病灶的生长情况.结果 治疗组的EMs病灶体积(8.58±2.31)mm3缩小,与生理盐水组(118.71±10.96)mm3及空白对照组(123.44±12.01)mm3比较差异有显著性(P＜0.05).结论 HIF-1α单克隆抗体治疗使SCID小鼠EMs病灶体积缩小,对EMs有治疗作用.
Abstract：?
Objective To explore the therapeutic effect of using hypoxia-inducible factor(HIF)-1 α monoclonal antibody to treat SCID mouse models of endometriosis. Methods Successful mouse models were randomized into three groups: receive routine feeding group ( control group, n=10), an intrafocal injection of normal saline group ( NS group, n=10), and an intrafocal injection of HIF-1 α monoclonal antibody group (250 μ g/0.25 ml per one; treatment group, n=10). The injection was repeated one week later. All mice were killed one week after the second injection. Observed the changes in size and shape of the implants. Results The implant volume was significantly reduced in the treatment group. Conclusions HIF-1 αt monoclonal antibody has a therapeutic effect on SCID mouse model of Ems.
doi： 10.3760/cma.j.issn.1007-1245.2011.16.009
作者： 任旭 [1]戴丽冰 [2]
Author： REN Xu [1] DAI Li-bing [2]
作者单位： 广州市红十字会医院妇产科,510220 广州市红十字会医院创伤外科研究所,510220
刊 名： 国际医药卫生导报
Journal： INTERNATIONAL MEDICINE AND HEALTH GUIDANCE NEWS
年，卷(期)： 2011, 17(16)
关键词： 子宫内膜异位症 缺氧诱导因子-1α 单克隆抗体 SCID小鼠
Keywords： endometriosishypoxia-inducible factor-1 αmonoclonal antibodySCID mice
在线出版日期： 2011年10月28日
基金项目： 广州市医药卫生科技技能引导项目
原文网址：- http://d.wanfangdata.com.cn/Periodical/gjyywsdb201116009
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发表于 2011-10-28 00:00:00
